Genetic variant
rs7726159
rs7726159 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7726159 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Evaluation of Candidate Stromal Epithelial Cross-Talk Genes Identifies Association between Risk of Serous Ovarian Cancer and TERT, a Cancer Susceptibility "Hot-Spot
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7726159, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7726159
- Position
- chr5:1282204
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Leukocyte telomere length | A | β 0.07 | 1E-174 | PubMed |
| red blood cell count (RBC, maximum, inv-norm transformed) | C | β 0.068 | 1E-135 | PubMed |
| Red blood cell count | A | β 0.026 | 1E-101 | PubMed |
| red blood cell count (RBC, mean, inv-norm transformed) | C | β 0.057 | 7E-100 | PubMed |
| Telomere length | — | — | 4E-87 | PubMed |
| Red blood cell count | A | β 0.033 | 4E-74 | PubMed |
| red blood cell count (RBC, maximum, inv-norm transformed) | C | β 0.05 | 5E-61 | PubMed |
| red blood cell count (RBC, minimum, inv-norm transformed) | C | β 0.039 | 3E-50 | PubMed |
| red blood cell count (RBC, mean, inv-norm transformed) | C | β 0.043 | 1E-48 | PubMed |
| Lung cancer in never smokers | A | OR 1.42 | 1E-46 | PubMed |
| Uterine fibroids | A | β 0.088 | 5E-42 | PubMed |
| White blood cell count | A | β 0.027 | 1E-36 | PubMed |
| Red blood cell count | A | β 0.043 | 1E-36 | PubMed |
| Thyroid cancer | A | OR 0.15 | 3E-31 | PubMed |
| red blood cell count (RBC, minimum, inv-norm transformed) | C | β 0.03 | 5E-29 | PubMed |
| Lung cancer | — | β 0.099 | 6E-26 | PubMed |
| Cancer within the respiratory system (PheCode 165) | — | — | 4E-19 | PubMed |
| Cancer of bronchus; lung (PheCode 165.1) | — | — | 7E-18 | PubMed |
| mean corpuscular volume (MCV, mean, inv-norm transformed) | C | β 0.054 | 8E-18 | PubMed |
| White blood cell count | A | β 0.032 | 3E-17 | PubMed |
Sources
- dbSNP: rs7726159 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies