Genetic variant
rs735665
rs735665 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs735665 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
23andMe blog chronic lymphocytic leukemia *rs735665 A 1.45 news Slager and colleagues validated thes...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs735665, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs735665
- Position
- chr11:123490689
Genome-wide association studies (17)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Chronic lymphocytic leukemia | A | OR 1.62 | 4E-39 | PubMed |
| Chronic lymphocytic leukemia | A | OR 1.64 | 4E-24 | PubMed |
| IgM levels | A | OR 0.15 | 1E-23 | PubMed |
| Leukemia (PheCode 204) | G | OR 0.19 | 1E-20 | PubMed |
| Leukemia (PheCode 204) | G | OR 0.2 | 8E-20 | PubMed |
| lymphocyte (fraction, mean, inv-norm transformed) | G | β 0.031 | 1E-18 | PubMed |
| lymphocyte (fraction, maximum, inv-norm transformed) | G | β 0.028 | 9E-16 | PubMed |
| lymphocyte (absolute count, mean, inv-norm transformed) | G | β 0.031 | 6E-15 | PubMed |
| lymphocyte (fraction, mean, inv-norm transformed) | G | β 0.029 | 1E-14 | PubMed |
| lymphocyte (fraction, maximum, inv-norm transformed) | G | β 0.027 | 4E-13 | PubMed |
| lymphocyte (absolute count, maximum, inv-norm transformed) | G | β 0.029 | 1E-12 | PubMed |
| Chronic lymphocytic leukemia | A | OR 1.52 | 3E-12 | PubMed |
| Chronic lymphocytic leukemia | A | OR 1.45 | 4E-12 | PubMed |
| IGHM protein levels | — | OR 0.24 | 2E-9 | PubMed |
| Chronic lymphocytic leukemia | — | OR 1.42 | 3E-9 | PubMed |
| Follicular lymphoma | T | OR 1.81 | 4E-9 | PubMed |
| CD5L protein levels | — | OR 0.23 | 5E-9 | PubMed |
Sources
- dbSNP: rs735665 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies