RS727479 CYP19A1

Drug Response Chr 15:51242349 snv intron variant

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What This Variant Does

"endometrial cancer rs727479(A) odds ratio per allele of 1.08, 95&#37

Associated Conditions

Letrozole response

GWAS Studies (8)

Trait	Risk Allele	OR / Beta	P-value	Study
Estradiol levels	A	OR: 1.39	8E-30	PubMed
Estrone levels	A	OR: 2.09	2E-22	PubMed
Testosterone to estradiol ratio	A	OR: 0.14	4E-21	PubMed
Waist-hip index	C	β: 0.022	5E-11	PubMed
Waist-to-hip ratio adjusted for BMI	C	β: 0.021	7E-11	PubMed
Testosterone to estradiol ratio	A	OR: 0.12	2E-9	PubMed
Pelvic bone marrow fat fraction	A	β: 0.056	1E-8	PubMed
Estradiol levels	C	OR: 0.11	5E-7	PubMed

Population Frequencies

gnomAD ALL

1kG AFR

18.5%

1kG ALL

28.4%

1kG AMR

37.9%

1kG EAS

28.1%

1kG EUR

36.8%

1kG SAS

73.4%

Other Variants in CYP19A1