Genetic variant

rs718314

rs718314 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs718314 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs718314, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs718314
Position
chr12:26300350

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Waist-to-hip ratio adjusted for BMI G β 0.034 7E-64 PubMed
Waist-to-hip ratio adjusted for BMI G β 0.053 7E-59 PubMed
Waist-hip index G β 0.053 2E-58 PubMed
A body shape index G β 0.041 2E-35 PubMed
Waist circumference adjusted for body mass index G β 0.038 9E-30 PubMed
Waist-to-hip ratio adjusted for body mass index G β 0.04 3E-18 PubMed
Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) — — 4E-18 PubMed
Waist-hip ratio G β 0.03 1E-17 PubMed
Triglycerides to Total Lipids in Very Small VLDL percentage G β 0.02 2E-16 PubMed
Renal cell carcinoma — OR 1.18 2E-16 PubMed
Phospholipids to Total Lipids in Small VLDL percentage G β 0.02 7E-16 PubMed
Cholesteryl Esters to Total Lipids in Very Small VLDL percentage G β 0.02 9E-16 PubMed
Cholesterol to Total Lipids in Very Small VLDL percentage G β 0.02 2E-15 PubMed
Free Cholesterol to Total Lipids in Very Large VLDL percentage G β 0.02 7E-15 PubMed
Waist-to-hip ratio adjusted for BMI in active individuals G β 0.052 7E-15 PubMed
Triglycerides to Total Lipids in Small VLDL percentage G β 0.02 9E-15 PubMed
Triglycerides A β 0.018 9E-15 PubMed
Cholesterol to Total Lipids in Small VLDL percentage G β 0.02 7E-14 PubMed
Triglycerides to Total Lipids in Small LDL percentage G β 0.02 1E-13 PubMed
Reticulocyte count G β 0.019 3E-13 PubMed

Sources