Genetic variant
rs7157785
rs7157785 is a single-letter difference in human DNA, on chromosome 14. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7157785 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7157785, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7157785
- Position
- chr14:63768838
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Sphingomyelin_32:1_[M+H]1+ levels | T | OR 0.44 | 7E-172 | PubMed |
| Sphingomyelin (d18:1/15:0, d16:1/17:0) levels | T | OR 0.36 | 6E-154 | PubMed |
| Diacylglycerol_42:7_[M+H-H2O]1+ levels | T | OR 0.38 | 2E-136 | PubMed |
| Phosphatidylcholine diacyl C28:1 levels | T | OR 24.83 | 5E-136 | PubMed |
| X-08402-to-cholesterol ratio | T | β 0.065 | 1E-133 | PubMed |
| Hydroxysphingomyeline C14:1 levels | T | OR 20.85 | 2E-96 | PubMed |
| Sphingomyelin (d32:1) levels | T | OR 0.51 | 3E-95 | PubMed |
| Sphingomyelin_39:1_[M+H]1+ levels | T | OR 0.32 | 4E-91 | PubMed |
| Triacylglycerol_45:4_[M+NH4]1+ levels | T | OR 0.32 | 5E-90 | PubMed |
| X-08402 levels | T | β 0.068 | 7E-87 | PubMed |
| Phosphatidylcholine-O_36:1_[M+H]1+/Phosphatidylcholine-P_36:0_[M+H]1+/Phosphatidylethanolamine-O_39:1_[M+H]1+ levels | T | OR 0.3 | 7E-84 | PubMed |
| Sphingomyelin_33:1_[M+H]1+ levels | T | OR 0.29 | 4E-74 | PubMed |
| Sphingomyelin_38:1_[M+H]1+ levels | T | OR 0.29 | 1E-73 | PubMed |
| Phosphatidylcholine-O_30:1_[M+H]1+/Phosphatidylcholine-P_30:0_[M+H]1+/Phosphatidylethanolamine-O_33:1_[M+H]1+ levels | T | OR 0.26 | 3E-70 | PubMed |
| Sphingolipid levels | A | β 0 | 9E-66 | PubMed |
| Phosphatidylcholine diacyl C28:1 levels | T | OR 0.11 | 4E-63 | PubMed |
| Phosphatidylglycerol-O_40:0_[M-H]1- levels | T | OR 0.2 | 3E-57 | PubMed |
| Sphingomyelin (d32:1) levels | T | OR 0.5 | 4E-52 | PubMed |
| Sphingomyelin (d38:1) levels | T | OR 0.37 | 1E-49 | PubMed |
| Sphingomyelin (d40:2) levels | T | OR 0.34 | 2E-41 | PubMed |
Sources
- dbSNP: rs7157785 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies