Genetic variant
rs7132908
rs7132908 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs7132908 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs7132908, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs7132908
- Position
- chr12:49869365
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Weight (mean, inv-normal transformed) | G | β 0.071 | 7E-135 | PubMed |
| Weight (maximum, inv-normal transformed) | G | β 0.071 | 6E-133 | PubMed |
| Body mass index (BMI, maximum, inv-normal transformed) | G | β 0.068 | 1E-120 | PubMed |
| Body mass index (BMI, mean, inv-normal transformed) | G | β 0.068 | 2E-120 | PubMed |
| Weight (minimum, inv-normal transformed) | G | β 0.06 | 1E-104 | PubMed |
| Body size at age 10 | G | β 0.031 | 2E-104 | PubMed |
| Body mass index (BMI, minimum, inv-normal transformed) | G | β 0.056 | 3E-90 | PubMed |
| Childhood body mass index | G | β 0.04 | 2E-77 | PubMed |
| Body mass index | A | β 0.031 | 2E-76 | PubMed |
| Weight | A | β 0.025 | 3E-72 | PubMed |
| Body mass index | A | β 0.031 | 5E-64 | PubMed |
| Weight (maximum, inv-normal transformed) | G | β 0.055 | 2E-53 | PubMed |
| Weight (mean, inv-normal transformed) | G | β 0.054 | 2E-52 | PubMed |
| Body mass index (BMI, maximum, inv-normal transformed) | G | β 0.053 | 5E-51 | PubMed |
| Body mass index (BMI, mean, inv-normal transformed) | G | β 0.052 | 6E-51 | PubMed |
| Body mass index | — | — | 5E-50 | PubMed |
| Weight (UKB data field 21002) | A | β 0.024 | 2E-49 | PubMed |
| Body mass index | — | — | 3E-49 | PubMed |
| Body mass index | G | β 0.029 | 4E-48 | PubMed |
| Weight | A | β 0.025 | 2E-46 | PubMed |
Sources
- dbSNP: rs7132908 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies