Genetic variant
rs6993770
rs6993770 is a single-letter difference in human DNA, on chromosome 8. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6993770 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6993770, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6993770
- Position
- chr8:105569300
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| EDAR/ENO2 protein level ratio | — | OR 0.41 | 1E-646 | PubMed |
| CD69/EDAR protein level ratio | — | OR 0.4 | 2E-604 | PubMed |
| CD40LG/EDAR protein level ratio | — | OR 0.37 | 8E-533 | PubMed |
| EDAR/F2R protein level ratio | — | OR 0.36 | 1E-502 | PubMed |
| CD63/EDAR protein level ratio | — | OR 0.35 | 2E-477 | PubMed |
| EDAR/EGF protein level ratio | — | OR 0.35 | 4E-475 | PubMed |
| EDAR/SERPINB1 protein level ratio | — | OR 0.34 | 2E-448 | PubMed |
| ANXA3/EDAR protein level ratio | — | OR 0.34 | 9E-431 | PubMed |
| EDAR/SNAP23 protein level ratio | — | OR 0.33 | 7E-423 | PubMed |
| CRADD/EDAR protein level ratio | — | OR 0.33 | 3E-412 | PubMed |
| DBNL/EDAR protein level ratio | — | OR 0.33 | 1E-411 | PubMed |
| EDAR/TXNDC5 protein level ratio | — | OR 0.32 | 6E-397 | PubMed |
| EDAR/F11R protein level ratio | — | OR 0.32 | 1E-395 | PubMed |
| EDAR/SDC4 protein level ratio | — | OR 0.32 | 1E-389 | PubMed |
| EBAG9/EDAR protein level ratio | — | OR 0.32 | 1E-387 | PubMed |
| EDAR/SPARC protein level ratio | — | OR 0.31 | 2E-376 | PubMed |
| EDAR/TACC3 protein level ratio | — | OR 0.31 | 4E-368 | PubMed |
| EDAR/TMSB10 protein level ratio | — | OR 0.31 | 5E-362 | PubMed |
| EDAR/PRDX5 protein level ratio | — | OR 0.31 | 9E-361 | PubMed |
| EDAR/IRAK4 protein level ratio | — | OR 0.3 | 8E-352 | PubMed |
Sources
- dbSNP: rs6993770 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies