Genetic variant
rs6882046
rs6882046 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6882046 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genome-wide association study identifies 74 loci associated with educational attainment.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6882046, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6882046
- Position
- chr5:88673046
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Vertex-wise cortical surface area | G | OR 9.99 | 2E-23 | PubMed |
| Intelligence (MTAG) | A | β 0.027 | 3E-16 | PubMed |
| Neuroticism | A | OR 7.89 | 3E-15 | PubMed |
| Alzheimer's disease or educational attainment (pleiotropy) | A | OR 69.48 | 3E-14 | PubMed |
| Intelligence | A | OR 7.56 | 4E-14 | PubMed |
| Attention deficit hyperactivity disorder or autism spectrum disorder or intelligence (pleiotropy) | — | — | 6E-14 | PubMed |
| Educational attainment (years of education) | A | β 0.019 | 8E-14 | PubMed |
| Red wine consumption (glasses per month) (UKB data field 1578, 4419) | A | β 0.019 | 4E-13 | PubMed |
| Neuroticism | A | OR 7.19 | 6E-13 | PubMed |
| Income (MTAG) | — | β 0.014 | 7E-13 | PubMed |
| Neuroticism conditioned on educational attainment (multi-trait conditioning and joint analysis) | — | — | 3E-11 | PubMed |
| General cognitive ability | A | OR 6.62 | 4E-11 | PubMed |
| Frailty (Factor 5 - Poorer Cognition) | — | — | 8E-11 | PubMed |
| Depression | A | β 0.021 | 1E-10 | PubMed |
| Participation in an health questionnaire (not invited vs invited) | A | OR 1.01 | 2E-10 | PubMed |
| Educational attainment (college completion) | — | OR 1.04 | 2E-10 | PubMed |
| Neuroticism conditioned on average household income before tax (multi-trait conditioning and joint analysis) | — | — | 4E-10 | PubMed |
| Occipital area (unadjusted for global measures) | — | β 0.05 | 5E-10 | PubMed |
| Occipital area | — | β 0.045 | 7E-10 | PubMed |
| Household income (MTAG) | G | β 0.014 | 7E-10 | PubMed |
Sources
- dbSNP: rs6882046 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies