Genetic variant
rs687289
rs687289 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs687289 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs687289, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs687289
- Position
- chr9:133261703
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| vWF levels | A | OR 0.2 | 5E-1443 | PubMed |
| Factor VIII levels | A | OR 0.14 | 2E-770 | PubMed |
| Venous thromboembolism | A | OR 0.29 | 7E-507 | PubMed |
| Factor VIII levels | — | OR 17.7 | 5E-324 | PubMed |
| Venous thromboembolism or tissue plasminogen activator levels (pleiotropy) | — | — | 5E-175 | PubMed |
| Venous thromboembolism | A | OR 1.34 | 1E-174 | PubMed |
| Venous thromboembolism or plasminogen activator inhibitor 1 levels (pleiotropy) | — | — | 3E-174 | PubMed |
| Venous thromboembolism | — | OR 0.29 | 2E-172 | PubMed |
| ENTPD6 protein levels | A | OR 0.12 | 8E-133 | PubMed |
| Monocyte count (UKB data field 30130) | A | β 0.039 | 2E-86 | PubMed |
| Deep venous thrombosis | A | OR 0.3 | 4E-80 | PubMed |
| Activated partial thromboplastin time | — | OR 0.13 | 9E-68 | PubMed |
| Coagulation factor levels | A | OR 0.36 | 7E-50 | PubMed |
| Blood protein levels | — | OR 0.74 | 1E-40 | PubMed |
| Monocyte count | G | — | 5E-37 | PubMed |
| FGF23 protein levels | A | β 0.07 | 2E-34 | PubMed |
| MLN protein levels | A | β 0.055 | 2E-33 | PubMed |
| CD28 protein levels | A | β 0.065 | 3E-30 | PubMed |
| Chronic thromboembolic pulmonary hypertension | — | OR 1.8 | 7E-27 | PubMed |
| Monocyte count | A | β 0.04 | 8E-26 | PubMed |
Sources
- dbSNP: rs687289 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies