Genetic variant
rs6857
rs6857 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6857 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6857, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6857
- Position
- chr19:44888997
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| LDL cholesterol levels | C | OR 0.16 | 1E-711 | PubMed |
| D-3-phosphoglycerate dehydrogenase levels | T | OR 0.74 | 8E-422 | PubMed |
| Dementias (PheCode 290.1) | C | OR 0.51 | 1E-323 | PubMed |
| Dementias (PheCode 290.1) | C | OR 0.55 | 1E-323 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | T | — | 2E-277 | PubMed |
| Alzheimer's disease | T | — | 2E-189 | PubMed |
| Brain amyloid deposition (PET imaging) | T | OR 1.67 | 6E-132 | PubMed |
| Omega-6 fatty acid levels | T | — | 5E-121 | PubMed |
| Linoleic acid levels | T | — | 1E-120 | PubMed |
| Polyunsaturated fatty acid levels | T | — | 2E-116 | PubMed |
| Total fatty acid levels | T | — | 8E-101 | PubMed |
| LDL cholesterol levels x long total sleep time interaction (2df test) | — | OR 6.46 | 3E-98 | PubMed |
| Total fatty acid levels | T | — | 1E-71 | PubMed |
| Monounsaturated fatty acid levels | T | — | 2E-69 | PubMed |
| Saturated fatty acids levels | T | — | 5E-67 | PubMed |
| Polyunsaturated fatty acid levels | T | — | 5E-55 | PubMed |
| Total fatty acid levels | T | — | 2E-47 | PubMed |
| Neuritic plaque | T | OR 0.95 | 3E-47 | PubMed |
| Neurofibrillary tangles | T | OR 0.79 | 5E-44 | PubMed |
| Saturated fatty acids levels | T | — | 7E-42 | PubMed |
Sources
- dbSNP: rs6857 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies