RS6742078 UGT1A10

Health Risk Chr 2:233763992 snv intron variant

Upload your DNA to see your genotype for this variant.

What This Variant Does

"Xenobiotic metabolizing gene variants, dietary heterocyclic amine intake, and risk of prostate cance...

Associated Conditions

BILIRUBIN

SERUM LEVEL OF

QUANTITATIVE TRAIT LOCUS 1

Gilbert syndrome

BILIRUBIN

SERUM LEVEL OF

QUANTITATIVE TRAIT LOCUS 1

Gilbert syndrome

GWAS Studies (20)

Trait	Risk Allele	OR / Beta	P-value	Study
Bilirubin levels	T	OR: 0.23	5E-324	PubMed
Plasma bilirubin degradation product, C17H18N2O4 (2)** levels in chronic kidney disease	T	OR: 0.44	4E-195	PubMed
Bilirubin levels	—	OR: 0.18	1E-158	PubMed
Bilirubin degradation product, C17H20N2O5 (1) levels	T	OR: 0.39	9E-135	PubMed
Bilirubin levels	—	OR: 0.17	2E-78	PubMed
Direct bilirubin levels x insomnia interaction	—	—	3E-69	PubMed
Total bilirubin levels x insomnia interaction	—	—	3E-69	PubMed
UDP-glucuronosyltransferase 1-6 levels	T	OR: 0.24	6E-69	PubMed
Serum metabolite levels	—	β: 0.086	2E-38	PubMed
Serum levels of protein UGT1A6	T	OR: 0.26	2E-36	PubMed
Total bilirubin x commonly-tested environments (Sex, Age, Ever-drinking, Ever-smoking, and Current-smoking) interaction	T	—	2E-30	PubMed
Total bilirubin levels	T	OR: 0.53	4E-28	PubMed
Circulating cell-free DNA	T	OR: 0.34	2E-23	PubMed
Abnormal results of function study of liver (PheCode 573.7)	G	β: 0.072	1E-21	PubMed
Total bilirubin x current-smoking interaction	T	β: 0.047	1E-21	PubMed
Bilirubin (z,z) levels	—	OR: 0.73	3E-20	PubMed
Serum levels of protein CKAP4	T	OR: 0.19	1E-19	PubMed
X-11530 levels	—	OR: 0.68	4E-17	PubMed
X-24849 levels	—	OR: 0.72	3E-16	PubMed
X-21448 levels	—	OR: 0.79	5E-16	PubMed

ClinVar Assertions (2)

NM_000463.3(UGT1A1):c.864+2842G>T

· 2 submitters

NM_000463.3(UGT1A1):c.864+2842G>T

· 2 submitters

Population Frequencies

1kG AFR

52.9%

1kG ALL

34.8%

1kG AMR

37.8%

1kG EAS

87%

1kG EUR

70.2%

1kG SAS

56.5%