Genetic variant
rs6733839
rs6733839 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6733839 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs6733839 is a SNP in the bridging integrator 1 BIN1 gene. BIN1 is a well established risk gene for ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6733839, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6733839
- Position
- chr2:127135234
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Alzheimer's disease | T | OR 1.17 | 6E-118 | PubMed |
| Alzheimer's disease | T | — | 6E-92 | PubMed |
| Alzheimer's disease | T | OR 1.18 | 4E-90 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | — | OR 1.15 | 2E-64 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | — | OR 0.16 | 1E-54 | PubMed |
| Alzheimer's disease (late onset) | T | OR 1.22 | 7E-44 | PubMed |
| Alzheimer's disease (age of onset) | T | β 0.065 | 2E-37 | PubMed |
| Lewy body dementia (MTAG) | T | OR 11.68 | 2E-31 | PubMed |
| Alzheimer's disease | — | OR 1.2 | 3E-30 | PubMed |
| Alzheimer's disease (late onset) | T | OR 11.3 | 1E-29 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | T | OR 11.3 | 1E-29 | PubMed |
| Family history of Alzheimer's disease | — | OR 1.11 | 1E-27 | PubMed |
| Alzheimer's disease | T | OR 1.12 | 7E-26 | PubMed |
| Alzheimer's disease or HDL levels (pleiotropy) | — | — | 3E-25 | PubMed |
| Maternal history of Alzheimer's disease | — | OR 1.12 | 4E-21 | PubMed |
| Alzheimer's disease (adjusted for APOE e4 dosage) | T | OR 1.15 | 2E-20 | PubMed |
| Alzheimer's disease | — | OR 1.23 | 5E-20 | PubMed |
| Serum levels of protein BIN1 | T | OR 0.15 | 3E-14 | PubMed |
| Transmembrane protein 132C:Cytoplasmic domain levels | T | OR 0.18 | 7E-14 | PubMed |
| Alzheimer's disease or family history of Alzheimer's disease | T | — | 6E-12 | PubMed |
Sources
- dbSNP: rs6733839 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies