Genetic variant
rs6672420
rs6672420 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6672420 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Significant association of RUNX3 T/A polymorphism at intron 3 (rs760805) with the risk of gastric atrophy in Helicobacter pylori seropositive Japanese
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6672420, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs6672420
- Position
- chr1:24964519
Genome-wide association studies (14)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Psoriasis (PheCode 696.4) | A | β 0.099 | 7E-20 | PubMed |
| Psoriasis vulgaris (PheCode 696.41) | A | OR 0.1 | 8E-20 | PubMed |
| Psoriasis vulgaris (PheCode 696.41) | A | β 0.099 | 2E-19 | PubMed |
| Psoriasis and related disorder (PheCode 696) | A | β 0.096 | 5E-19 | PubMed |
| Atopic/contact dermatitis due to other or unspecified (PheCode 939) | A | β 0.043 | 4E-15 | PubMed |
| Atopic/contact dermatitis due to other or unspecified (PheCode 939) | A | β 0.043 | 2E-13 | PubMed |
| Skin condition (ex. Eczema, Psoriasis) | A | β 0.053 | 2E-12 | PubMed |
| Psoriasis or type 2 diabetes (trans-disease meta-analysis)(opposite effect) | T | OR 1.07 | 3E-12 | PubMed |
| Eczema | T | OR 1.08 | 5E-12 | PubMed |
| White blood cell count | A | β 0.009 | 6E-11 | PubMed |
| Psoriasis vulgaris | T | OR 0.12 | 7E-10 | PubMed |
| Multiple sclerosis | A | OR 1.06 | 1E-9 | PubMed |
| Atopic dermatitis | A | β 0.048 | 4E-9 | PubMed |
| White blood cell count | — | — | 2E-8 | PubMed |
Sources
- dbSNP: rs6672420 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies