Genetic variant

rs6589564

rs6589564 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6589564 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations: 10-Year Follow-Up of the GLACIER Study

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6589564, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs6589564
Position
chr11:116753437

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Serum levels of protein NXPH2 C OR 0.41 3E-29 PubMed
Free cholesterol to total lipids ratio in very large VLDL C β 0.089 4E-26 PubMed
Cholesteryl esters to total lipids ratio in IDL C β 0.058 5E-14 PubMed
Sphingomyelin(38:1)_[M+H]1+ levels T β 0.081 1E-10 PubMed
Sphingomyelin(34:0)_[M+H]1+ levels G β 0.069 1E-10 PubMed
Cholesteryl ester(18:0)_[M+NH4]1+ levels A β 0.036 1E-10 PubMed
Cholesteryl ester(18:1)_[M+NH4]1+ levels C β 0.056 1E-10 PubMed
Sphingomyelin(41:2)_[M+H]1+ levels G OR 0.17 1E-10 PubMed
Cholesteryl ester(18:3)_[M+NH4]1+ levels A OR 0.11 1E-10 PubMed
Sphingomyelin(36:1)_[M+H]1+ levels A β 0.048 1E-10 PubMed
Triacylglycerol(54:4)_[M+NH4]1+ levels T β 0.096 1E-10 PubMed
Triacylglycerol(54:3)_[M+NH4]1+ levels T β 0.042 1E-10 PubMed
Sphingomyelin(34:1)_[M+H]1+ levels C β 0.022 1E-10 PubMed
Diacylglycerol(36:2)_[M+H-H2O]1+ levels G β 0.062 1E-10 PubMed
Diacylglycerol(36:3)_[M+H-H2O]1+ levels G β 0.051 1E-10 PubMed
Triacylglycerol(52:3)_[M+NH4]1+ levels C OR 0.15 1E-10 PubMed
Coronary artery disease or factor VII levels (pleiotropy) — — 1E-10 PubMed
Sphingomyelin(36:0)_[M+H]1+ levels T OR 0.25 1E-10 PubMed
Triacylglycerol(52:1)_[M+NH4]1+ levels T β 0.097 1E-10 PubMed
Cholesterol_[M+H-H2O]1+ levels G OR 0.25 1E-10 PubMed

Sources