Genetic variant
rs635634
rs635634 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs635634 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs635634, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs635634
- Position
- chr9:133279427
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Red blood cell count | T | β 0.057 | 5E-330 | PubMed |
| Serum levels of protein ICAM2 | T | OR 0.72 | 4E-158 | PubMed |
| Intercellular adhesion molecule 2 levels | — | OR 0.7 | 9E-134 | PubMed |
| Blood protein levels in cardiovascular risk | T | OR 0.41 | 7E-125 | PubMed |
| Tissue factor levels | T | OR 0.24 | 1E-107 | PubMed |
| Vascular endothelial growth factor receptor 2 levels (KDR.3651.50.5) | T | OR 0.58 | 4E-80 | PubMed |
| Leukemia inhibitory factor receptor levels | T | OR 0.29 | 3E-79 | PubMed |
| Total lipids in small HDL | T | β 0.05 | 8E-76 | PubMed |
| Venous thromboembolism | — | OR 1.6 | 2E-73 | PubMed |
| Low density lipoprotein cholesterol levels | C | OR 0.1 | 5E-66 | PubMed |
| Phospholipids in small HDL | T | β 0.04 | 1E-62 | PubMed |
| Gamma glutamyltransferase levels (UKB data field 30730) | T | β 0.037 | 2E-60 | PubMed |
| Gamma glutamyl transferase levels | T | β 0.011 | 2E-57 | PubMed |
| Free cholesterol in small HDL | T | β 0.04 | 9E-57 | PubMed |
| P-selectin levels | C | OR 0.16 | 1E-55 | PubMed |
| Total cholesterol levels | C | OR 0.13 | 8E-55 | PubMed |
| Liver enzyme levels (gamma-glutamyl transferase) | C | β 0.01 | 2E-52 | PubMed |
| Total cholesterol in very small VLDL | T | β 0.075 | 3E-51 | PubMed |
| Cholesterol esters in very small VLDL | T | β 0.074 | 2E-50 | PubMed |
| C-C motif chemokine 25 levels | T | OR 0.25 | 2E-50 | PubMed |
Sources
- dbSNP: rs635634 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies