Genetic variant
rs61751507
rs61751507 is a single-letter difference in human DNA, on chromosome 10. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs61751507 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs61751507, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs61751507
- Position
- chr10:100069757
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Apolipoprotein L1 levels (APOL1.9506.10.3) | T | OR 1.33 | 4E-127 | PubMed |
| Protocadherin alpha-7 levels (PCDHA7.8758.2.3) | T | OR 0.89 | 2E-52 | PubMed |
| Calpastatin levels | T | OR 0.61 | 6E-41 | PubMed |
| Neutrophil collagenase levels (MMP8.2954.56.2) | T | OR 0.78 | 3E-40 | PubMed |
| GNLY protein levels | T | OR 0.16 | 1E-38 | PubMed |
| Protocadherin alpha-7 levels | T | OR 0.39 | 9E-32 | PubMed |
| Calpastatin levels (CAST.3026.5.2) | T | OR 0.67 | 7E-30 | PubMed |
| Calcium/calmodulin-dependent protein kinase type 1 levels (CAMK1.3592.4.3) | T | OR 0.65 | 2E-28 | PubMed |
| total creatine kinase (mean, inv-norm transformed) | C | OR 0.11 | 7E-22 | PubMed |
| Cell growth regulator with EF hand domain protein 1 levels (CGREF1.6257.56.3) | T | OR 0.54 | 5E-20 | PubMed |
| total creatine kinase (mean, inv-norm transformed) | C | OR 0.1 | 7E-20 | PubMed |
| total creatine kinase (maximum, inv-norm transformed) | C | β 0.094 | 9E-18 | PubMed |
| Creatine kinase levels | — | OR 0.12 | 6E-17 | PubMed |
| total creatine kinase (maximum, inv-norm transformed) | C | β 0.09 | 3E-15 | PubMed |
| Serum levels of protein FGFBP3 | T | OR 0.33 | 5E-14 | PubMed |
| KLK15 protein levels | T | β 0.085 | 1E-13 | PubMed |
| Serum levels of protein MMP8 | T | OR 0.34 | 2E-13 | PubMed |
| Granulysin levels | T | OR 0.3 | 4E-11 | PubMed |
| Creatine kinase levels | T | β 0.091 | 5E-11 | PubMed |
Sources
- dbSNP: rs61751507 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies