Genetic variant
rs61734651
rs61734651 is a single-letter difference in human DNA, on chromosome 20. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs61734651 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs61734651, most commonly known as the Trp3 allele yet technically also known as c.307C>
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs61734651, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs61734651
- Position
- chr20:62819980
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| height (mean, inv-normal transformed) | C | OR 0.11 | 2E-61 | PubMed |
| height (minimum, inv-normal transformed) | C | OR 0.1 | 2E-58 | PubMed |
| Height (maximum, inv-normal transformed) | C | OR 0.1 | 3E-58 | PubMed |
| What is your height? (cm, inv-normal transformed) | C | β 0.084 | 9E-31 | PubMed |
| Waist circumference adjusted for body mass index | — | — | 4E-21 | PubMed |
| Impedance of arm left (UKB data field 23110) | T | β 0.025 | 1E-20 | PubMed |
| Impedance of whole body (UKB data field 23106) | T | β 0.025 | 3E-19 | PubMed |
| COL9A1 protein levels | T | β 0.097 | 4E-19 | PubMed |
| height (minimum, inv-normal transformed) | C | β 0.084 | 2E-16 | PubMed |
| height (mean, inv-normal transformed) | C | β 0.085 | 1E-15 | PubMed |
| Height (maximum, inv-normal transformed) | C | β 0.081 | 5E-15 | PubMed |
| Physical function (baseline) | C | β 0.013 | 2E-10 | PubMed |
| Hearing loss | — | OR 1.06 | 2E-9 | PubMed |
| Waist-hip ratio | — | — | 5E-9 | PubMed |
| Age-related hearing impairment | T | β 0.011 | 8E-9 | PubMed |
| Hearing problems | — | β 0.033 | 2E-8 | PubMed |
Sources
- dbSNP: rs61734651 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies