RS60910145 APOL1
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What This Variant Does
"The derived allele of coding SNP rs60910145 (p.I384M) defines, together with the derived allele of c...
Associated Conditions
Hyalinosis
Segmental Glomerular
Glomerulonephritis
Nephrotic range proteinuria
Proteinuria
Focal segmental glomerulosclerosis
Steroid-resistant nephrotic syndrome
Sickled erythrocytes
APOL1-associated kidney disease
Focal segmental glomerulosclerosis 4
susceptibility to
Hyalinosis
Segmental Glomerular
Glomerulonephritis
Nephrotic range proteinuria
GWAS Studies (11)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Chronic renal failure [CKD] (PheCode 585.3) | T | OR: 0.14 | 3E-26 | PubMed |
| Chronic renal failure [CKD] (PheCode 585.3) | T | OR: 0.14 | 7E-26 | PubMed |
| Disorders of calcium/phosphorus metabolism (PheCode 275.5) | T | OR: 0.3 | 4E-22 | PubMed |
| Renal failure (PheCode 585) | T | OR: 0.11 | 6E-20 | PubMed |
| Disorders of phosphorus metabolism (PheCode 275.53) | T | OR: 0.36 | 2E-19 | PubMed |
| Renal failure (PheCode 585) | T | OR: 0.11 | 2E-19 | PubMed |
| Hypertensive heart and/or renal disease (PheCode 401.2) | T | OR: 0.12 | 3E-18 | PubMed |
| Hypertensive heart and/or renal disease (PheCode 401.2) | T | OR: 0.11 | 4E-18 | PubMed |
| Kidney disease with dialysis | T | OR: 0.44 | 9E-16 | PubMed |
| Kidney disease with dialysis | T | OR: 0.42 | 2E-14 | PubMed |
| Takes medication for kidney disease with dialysis? | T | OR: 0.4 | 4E-13 | PubMed |
Other Variants in APOL1