Genetic variant

rs6065906

rs6065906 is a single-letter difference in human DNA, on chromosome 20. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs6065906 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs6065906, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs6065906
Position
chr20:45925376

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Phospholipids to total lipids ratio in large HDL T OR 0.17 3E-237 PubMed
Concentration of small HDL particles (UKB data field 23572) C OR 0.18 1E-200 PubMed
Free Cholesterol to Total Lipids in Large LDL percentage C β 0.07 2E-185 PubMed
Phospholipids to total lipids in large HDL percentage (UKB data field 23634) C OR 0.17 3E-177 PubMed
Cholesteryl esters to total lipids in large HDL percentage (UKB data field 23636) C OR 0.14 3E-123 PubMed
Monounsaturated fatty acids to total fatty acids percentage C β 0.05 2E-110 PubMed
Metabolic signature — OR 0.12 3E-110 PubMed
Saturated fatty acids levels C — 2E-98 PubMed
Triglycerides in large HDL C β 0.069 2E-91 PubMed
Total fatty acid levels C — 3E-77 PubMed
PLTP protein levels — OR 0.72 6E-73 PubMed
Free cholesterol to total lipids in very large VLDL percentage (UKB data field 23587) C β 0.093 4E-56 PubMed
Metabolic syndrome — β 0.023 5E-49 PubMed
Lipid metabolism phenotypes — OR 0.69 1E-45 PubMed
HDL cholesterol C β 0.059 5E-40 PubMed
HDL cholesterol levels T β 0.059 6E-39 PubMed
Free cholesterol to total lipids in medium VLDL percentage (UKB data field 23597) C β 0.075 5E-38 PubMed
Triglycerides C β 0.053 2E-34 PubMed
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 levels T OR 0.21 3E-33 PubMed
Cholesteryl esters in very small VLDL (UKB data field 23520) C β 0.071 3E-33 PubMed

Sources