Genetic variant
rs601338
rs601338 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs601338 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs601338 is found on chromosome 19 in the alpha(1,2)-fucosyltransferase FUT2 gene. The wild-type rs6...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs601338, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs601338
- Position
- chr19:48703417
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| F3/KLK1 protein level ratio | — | OR 0.92 | 2E-4919 | PubMed |
| CCL25/PRSS27 protein level ratio | — | OR 0.64 | 6E-2144 | PubMed |
| CD55/CDH1 protein level ratio | — | OR 0.49 | 3E-1139 | PubMed |
| CDH1/HSPG2 protein level ratio | — | OR 0.46 | 8E-1012 | PubMed |
| CDH1/CST3 protein level ratio | — | OR 0.44 | 2E-943 | PubMed |
| CDH17/PTPRM protein level ratio | — | OR 0.42 | 1E-851 | PubMed |
| CDH17/SPINT1 protein level ratio | — | OR 0.42 | 5E-830 | PubMed |
| CDH17/PECAM1 protein level ratio | — | OR 0.4 | 8E-759 | PubMed |
| FAM3B/FGF19 protein level ratio | — | OR 0.34 | 6E-526 | PubMed |
| ERBB4/F3 protein level ratio | — | OR 0.32 | 1E-490 | PubMed |
| CGREF1/FAM3C protein level ratio | — | OR 0.32 | 2E-486 | PubMed |
| CELA3A/CPB1 protein level ratio | — | OR 0.29 | 1E-436 | PubMed |
| FAM3B/TMPRSS15 protein level ratio | — | OR 0.3 | 2E-423 | PubMed |
| CELA3A/CPA1 protein level ratio | — | OR 0.27 | 1E-371 | PubMed |
| FAM3B/GPA33 protein level ratio | — | OR 0.27 | 3E-355 | PubMed |
| Serine protease 27 levels | A | OR 0.5 | 9E-343 | PubMed |
| FGF19/SCG2 protein level ratio | — | OR 0.26 | 8E-314 | PubMed |
| Serum cancer antigen 19.9 levels | G | OR 0.57 | 1E-291 | PubMed |
| NECTIN4/SPINK5 protein level ratio | — | OR 0.24 | 4E-283 | PubMed |
| LEG1 protein levels | A | OR 0.19 | 6E-282 | PubMed |
Sources
- dbSNP: rs601338 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies