Genetic variant
rs600626
rs600626 is a single-letter difference in human DNA, on chromosome 11. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs600626 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs600626, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs600626
- Position
- chr11:75744264
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Phospholipids in HDL | G | β 0.06 | 2E-116 | PubMed |
| Free cholesterol in medium HDL | G | β 0.06 | 5E-112 | PubMed |
| Total Lipids in HDL | G | β 0.05 | 3E-95 | PubMed |
| Total concentration of lipoprotein particles | G | β 0.05 | 4E-89 | PubMed |
| Phosphoglycerides levels | G | β 0.04 | 1E-65 | PubMed |
| HDL cholesterol levels | G | β 0.04 | 4E-65 | PubMed |
| High density lipoprotein cholesterol levels | — | — | 5E-64 | PubMed |
| Phosphatidylcholine levels | G | β 0.04 | 1E-54 | PubMed |
| Total cholines levels | G | β 0.04 | 5E-51 | PubMed |
| Ratio of omega-3 fatty acids to total fatty acids | A | β 0.062 | 3E-30 | PubMed |
| 3-Hydroxybutyrate levels | G | β 0.03 | 1E-24 | PubMed |
| Estimated degree of unsaturation | A | β 0.053 | 5E-23 | PubMed |
| Degree of unsaturation (UKB data field 23443) | G | β 0.06 | 5E-22 | PubMed |
| Degree of unsaturation | G | — | 1E-19 | PubMed |
| Ratio of 22:6 docosahexaenoic acid to total fatty acids | A | β 0.046 | 2E-19 | PubMed |
| Cholesteryl Esters in IDL | G | β 0.02 | 2E-16 | PubMed |
| total cholesterol (mean, inv-norm transformed) | A | β 0.023 | 1E-13 | PubMed |
| Concentration of large HDL particles | A | β 0.036 | 8E-12 | PubMed |
| Metabolite peak levels (QI6701) | G | OR 0.2 | 1E-11 | PubMed |
| Total lipids in large HDL | A | β 0.035 | 2E-11 | PubMed |
Sources
- dbSNP: rs600626 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies