Genetic variant
rs58542926
rs58542926 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs58542926 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
The dual and opposite role of the TM6SF2-rs58542926 Variant in Protecting against Cardiovascular Disease and Conferring Risk for Non-alcoholic fatty liver: A meta-analysis
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs58542926, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs58542926
- Position
- chr19:19268740
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Total cholesterol levels | — | — | 2E-585 | PubMed |
| Omega-3 fatty acids levels | T | OR 0.17 | 1E-487 | PubMed |
| Non-HDL cholesterol levels | — | — | 3E-470 | PubMed |
| Triglyceride levels | — | — | 4E-413 | PubMed |
| Low density lipoprotein cholesterol levels | — | — | 8E-403 | PubMed |
| Total cholesterol levels | T | OR 0.13 | 2E-394 | PubMed |
| Omega-6 fatty acids to omega-3 fatty acids ratio | T | OR 0.15 | 3E-373 | PubMed |
| Omega-3 fatty acids | T | OR 0.23 | 4E-350 | PubMed |
| Non-HDL cholesterol levels | T | OR 0.14 | 1E-326 | PubMed |
| Omega-3 fatty acids to total fatty acids percentage | T | OR 0.14 | 4E-313 | PubMed |
| Low density lipoprotein cholesterol levels | T | OR 0.11 | 3E-291 | PubMed |
| Triglyceride levels | T | OR 0.11 | 9E-290 | PubMed |
| Omega-6 fatty acids to omega-3 fatty acids ratio | T | OR 0.19 | 1E-270 | PubMed |
| Total cholesterol levels | T | OR 0.15 | 6E-259 | PubMed |
| Omega-3 fatty acid levels | T | — | 6E-249 | PubMed |
| Triglyceride levels | T | OR 0.11 | 7E-246 | PubMed |
| triglyceride (mean, inv-norm transformed) | C | OR 0.18 | 3E-242 | PubMed |
| Docosahexaenoic acid levels | T | OR 0.12 | 2E-232 | PubMed |
| Omega-3 fatty acids to total fatty acids percentage | T | OR 0.18 | 3E-231 | PubMed |
| Low density lipoprotein cholesterol levels | T | OR 0.15 | 3E-228 | PubMed |
Sources
- dbSNP: rs58542926 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies