Genetic variant
rs579459
rs579459 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs579459 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Coronary Heart Disease [GWAS:Serum soluble E-selectin]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs579459, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs579459
- Position
- chr9:133278724
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Venous thromboembolism | C | OR 1.36 | 4E-145 | PubMed |
| Liver enzyme levels (alkaline phosphatase) | T | OR 8.8 | 3E-123 | PubMed |
| Low density lipoprotein cholesterol levels | T | OR 0.15 | 6E-60 | PubMed |
| LDL cholesterol levels | T | β 0.067 | 2E-51 | PubMed |
| Total cholesterol levels | T | OR 0.12 | 1E-48 | PubMed |
| Soluble levels of adhesion molecules | T | OR 14 | 2E-41 | PubMed |
| Urinary metabolites (H-NMR features) | T | OR 0.53 | 2E-32 | PubMed |
| Soluble E-selectin levels | C | — | 1E-29 | PubMed |
| ADpSGEGDFXAEGGGVR-to-X-14304--leucylalanine ratio | T | OR 0.12 | 1E-28 | PubMed |
| LDL cholesterol levels | T | OR 2.09 | 1E-26 | PubMed |
| Platelet glycoprotein 4 levels | C | OR 0.41 | 2E-23 | PubMed |
| Coronary artery disease | — | — | 2E-18 | PubMed |
| Red blood cell traits | T | β 0.021 | 9E-18 | PubMed |
| COVID-19 infection or age-related macular degeneration (MTAG) | — | β 0.01 | 2E-16 | PubMed |
| Hemoglobin concentration | C | β 0.079 | 2E-15 | PubMed |
| ZP3 protein levels | C | β 0.016 | 3E-15 | PubMed |
| Coronary heart disease | C | OR 1.1 | 4E-14 | PubMed |
| Hemoglobin concentration | C | OR 0.11 | 1E-13 | PubMed |
| LDL cholesterol | C | OR 2.85 | 6E-13 | PubMed |
| Total cholesterol levels | T | β 0.082 | 7E-13 | PubMed |
Sources
- dbSNP: rs579459 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies