Genetic variant
rs572515
rs572515 is a single-letter difference in human DNA, on chromosome 1. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs572515 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs572515 was the most significantly associated of a group of SNPs in the chromosome 1q32-33 region w...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs572515, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs572515
- Position
- chr1:196677131
Genome-wide association studies (18)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Serum levels of protein ANAPC7 | A | OR 0.42 | 4E-110 | PubMed |
| Serum levels of protein GSKIP | A | OR 0.34 | 1E-72 | PubMed |
| Copper homeostasis protein cutC homolog levels | A | OR 0.15 | 4E-26 | PubMed |
| Brain-specific angiogenesis inhibitor 1-associated protein 2 levels | A | OR 0.14 | 5E-22 | PubMed |
| Glycine cleavage system H protein, mitochondrial levels | A | OR 0.13 | 2E-19 | PubMed |
| Uncharacterized protein C1orf185 levels | A | OR 0.13 | 8E-19 | PubMed |
| Nodal homolog levels | A | OR 0.13 | 1E-18 | PubMed |
| Thioredoxin domain-containing protein 11 levels | A | OR 0.11 | 2E-14 | PubMed |
| Serum levels of protein CTXN3 | A | OR 0.14 | 4E-14 | PubMed |
| Replication protein A 32 kDa subunit levels | A | OR 0.11 | 4E-14 | PubMed |
| Insulin-like peptide INSL6 levels | A | OR 0.11 | 1E-13 | PubMed |
| Serum levels of protein NCF2 | A | OR 0.14 | 1E-13 | PubMed |
| Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 levels | A | OR 0.11 | 3E-13 | PubMed |
| Heat shock 70 kDa protein 13 levels | A | OR 0.1 | 5E-13 | PubMed |
| Calbindin levels | A | β 0.099 | 1E-12 | PubMed |
| Tumor necrosis factor ligand superfamily member 11 levels | A | OR 0.1 | 1E-12 | PubMed |
| Probable RNA-binding protein 46 levels | A | OR 0.1 | 2E-12 | PubMed |
| Serum levels of protein C10orf105 | A | OR 0.13 | 3E-12 | PubMed |
Sources
- dbSNP: rs572515 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies