Genetic variant
rs56137030
rs56137030 is a single-letter difference in human DNA, on chromosome 16. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs56137030 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A Systematic Mapping Approach of 16q12.2/FTO and BMI in More Than 20,000 African Americans Narrows in on the Underlying Functional Variation: Results from the Population Architecture using Genomics and Epidemiology (PAGE) Study
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs56137030, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs56137030
- Position
- chr16:53791993
Genome-wide association studies (11)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Atrial fibrillation | A | β 0.041 | 4E-28 | PubMed |
| Substance use disorder | A | OR 10.12 | 4E-24 | PubMed |
| Substance use disorder | A | — | 2E-23 | PubMed |
| Substance use disorder | A | OR 9.83 | 8E-23 | PubMed |
| Substance use disorder | A | OR 9.8 | 1E-22 | PubMed |
| Body mass index z-score | A | β 0.06 | 8E-20 | PubMed |
| Takes medication for high cholesterol? | G | β 0.046 | 1E-16 | PubMed |
| Gout | A | OR 1.08 | 2E-13 | PubMed |
| Tobacco use disorder | — | — | 3E-10 | PubMed |
| Body mass index | A | OR 0.38 | 3E-8 | PubMed |
| Body fat mass | — | β 0.07 | 5E-8 | PubMed |
Sources
- dbSNP: rs56137030 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies