Genetic variant
rs56113850
rs56113850 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs56113850 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Genome-wide association of the laboratory-based nicotine metabolite ratio in three ancestries.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs56113850, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs56113850
- Position
- chr19:40847202
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Nicotine metabolite ratio in current smokers | T | OR 0.68 | 6E-261 | PubMed |
| Cigarettes smoked per day | C | β 0.053 | 3E-214 | PubMed |
| Cigarettes smoked per day | C | β 0.056 | 6E-207 | PubMed |
| Smoking cessation | C | β 0.03 | 1E-120 | PubMed |
| Smoking cessation | C | β 0.03 | 5E-114 | PubMed |
| Alkaline phosphatase (UKB data field 30610) | C | β 0.039 | 6E-105 | PubMed |
| Smoking behaviour (cigarettes smoked per day) | C | β 0.052 | 4E-99 | PubMed |
| Serum alkaline phosphatase levels | C | β 0.047 | 1E-89 | PubMed |
| Nicotine metabolite ratio in current smokers | — | OR 0.65 | 6E-86 | PubMed |
| Cigarettes smoked per day (MTAG) | T | β 0.047 | 2E-78 | PubMed |
| Smoking behaviour (cigarettes smoked per day) | C | β 0.072 | 3E-68 | PubMed |
| Cigarettes smoked per day (MTAG) | C | β 0.036 | 5E-58 | PubMed |
| Nicotine metabolite ratio in current smokers | T | OR 0.36 | 1E-50 | PubMed |
| Smoking cessation | C | β 0.058 | 2E-48 | PubMed |
| 3-methylxanthine levels | T | OR 0.14 | 3E-44 | PubMed |
| Lung cancer | T | OR 0.89 | 1E-43 | PubMed |
| X-21286 levels | T | OR 0.13 | 7E-38 | PubMed |
| Nicotine metabolite ratio in current smokers | C | OR 0.75 | 1E-37 | PubMed |
| Glycine levels | C | β 0.02 | 1E-36 | PubMed |
| X-12216 levels | T | OR 0.13 | 7E-35 | PubMed |
Sources
- dbSNP: rs56113850 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies