Genetic variant
rs559555
rs559555 is a single-letter difference in human DNA, on chromosome 2. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs559555 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs559555, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs559555
- Position
- chr2:31585905
Genome-wide association studies (17)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| X-11444 levels | A | OR 0.21 | 9E-47 | PubMed |
| X-11444-to-X-12844 ratio | A | β 0.036 | 1E-44 | PubMed |
| X-11444 levels | A | OR 0.26 | 4E-41 | PubMed |
| X-11470 levels | A | OR 0.19 | 5E-36 | PubMed |
| Eicosanoid 11-dehydro-2,3-dinor-TXB2 a levels | — | OR 0.18 | 5E-32 | PubMed |
| X-11470 levels | A | OR 0.21 | 3E-26 | PubMed |
| Etiocholanolone glucuronide levels | A | OR 0.2 | 5E-24 | PubMed |
| X-11444 levels | A | β 0.033 | 4E-22 | PubMed |
| X-11470 levels | A | β 0.031 | 7E-19 | PubMed |
| Plasma X-11470 levels in chronic kidney disease | A | OR 0.14 | 4E-16 | PubMed |
| Eicosanoid 8-iso-PGA1, Eicosanoid PGA1 a levels | — | OR 0.12 | 2E-15 | PubMed |
| X-24494 levels | A | OR 0.17 | 6E-15 | PubMed |
| Androsterone glucuronide levels | A | OR 0.1 | 2E-14 | PubMed |
| 5alpha-pregnan-3beta,20beta-diol monosulfate (1) levels | A | β 0.074 | 2E-11 | PubMed |
| Plasma X-24494 levels in chronic kidney disease | A | OR 0.13 | 2E-11 | PubMed |
| Etiocholanolone glucuronide levels | A | OR 0.1 | 5E-11 | PubMed |
| Estradiol levels | T | β 0.006 | 6E-11 | PubMed |
Sources
- dbSNP: rs559555 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies