Genetic variant
rs55730499
rs55730499 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs55730499 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Reported to be associated with longevity
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs55730499, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs55730499
- Position
- chr6:160584578
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Total cholesterol levels | — | — | 6E-303 | PubMed |
| Coronary artery disease | — | — | 8E-186 | PubMed |
| Free Cholesterol to Total Lipids in Very Large VLDL percentage | T | OR 0.15 | 1E-174 | PubMed |
| Lipoprotein(a) levels adjusted for apolipoprotein(a) isoforms | T | OR 16.77 | 4E-163 | PubMed |
| Monounsaturated fatty acid levels | T | — | 2E-162 | PubMed |
| Coronary artery disease | T | OR 0.34 | 3E-154 | PubMed |
| Coronary artery disease | T | OR 0.34 | 3E-154 | PubMed |
| Coronary artery disease | T | OR 0.31 | 1E-153 | PubMed |
| Saturated fatty acids levels | T | — | 3E-143 | PubMed |
| Polyunsaturated fatty acids to total fatty acids percentage | T | — | 8E-136 | PubMed |
| Polyunsaturated fatty acids to monounsaturated fatty acids ratio | T | — | 3E-135 | PubMed |
| Free Cholesterol to Total Lipids in Medium VLDL percentage | T | OR 0.13 | 5E-134 | PubMed |
| Coronary artery disease or fibrinogen levels (pleiotropy) | — | — | 3E-124 | PubMed |
| Coronary artery disease or von Willebrand factor levels (pleiotropy) | — | — | 3E-122 | PubMed |
| Coronary artery disease or factor VIII levels (pleiotropy) | — | — | 4E-122 | PubMed |
| Monounsaturated fatty acids to total fatty acids percentage | T | — | 4E-122 | PubMed |
| Coronary artery disease or factor VII levels (pleiotropy) | — | — | 7E-122 | PubMed |
| Coronary artery disease or factor XI levels (pleiotropy) | — | — | 9E-122 | PubMed |
| Polyunsaturated fatty acids to saturated fatty acids ratio | T | — | 1E-111 | PubMed |
| Docosahexaenoic acid to total fatty acids percentage | T | β 0.08 | 2E-102 | PubMed |
Sources
- dbSNP: rs55730499 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies