RS4988235 MCM6
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What This Variant Does
"Also known as 'C/T(-13910)', and located in the MCM6 gene but with influence on the lactase LCT gene...
Associated Conditions
LACTASE PERSISTENCE
LACTASE PERSISTENCE
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Lactase-phlorizin hydrolase levels | A | OR: 0.88 | 3E-1451 | PubMed |
| Lactase-phlorizin hydrolase levels (LCT.9017.58.3) | A | OR: 0.78 | 2E-222 | PubMed |
| Blood protein levels | G | OR: 0.96 | 5E-210 | PubMed |
| Weight (maximum, inv-normal transformed) | G | β: 0.061 | 4E-85 | PubMed |
| Weight (mean, inv-normal transformed) | G | β: 0.06 | 1E-82 | PubMed |
| 1,5-anhydroglucitol (1,5-ag) levels | A | OR: 0.2 | 3E-72 | PubMed |
| Weight (minimum, inv-normal transformed) | G | β: 0.051 | 1E-65 | PubMed |
| Body mass index (BMI, maximum, inv-normal transformed) | G | β: 0.052 | 2E-59 | PubMed |
| Body mass index (BMI, mean, inv-normal transformed) | G | β: 0.05 | 8E-57 | PubMed |
| What is your weight? (pounds, inv-normal transformed) | G | β: 0.048 | 1E-44 | PubMed |
| 1,5-anhydroglucitol (1,5-ag) levels | A | OR: 0.27 | 5E-44 | PubMed |
| Body mass index (BMI, minimum, inv-normal transformed) | G | β: 0.042 | 2E-43 | PubMed |
| Gut microbial functional pathway relative abundance (KEGG-module M00233: Glutamate transport system) | A | OR: 0.13 | 3E-37 | PubMed |
| Gut microbial functional pathway relative abundance (KEGG-module M00443: SenX3-RegX3 (phosphate starvation response) two-component regulatory system) | A | OR: 0.13 | 6E-35 | PubMed |
| Weight (mean, inv-normal transformed) | G | β: 0.049 | 9E-35 | PubMed |
| Urine lactose levels in chronic kidney disease | A | OR: 0.24 | 4E-34 | PubMed |
| Weight (maximum, inv-normal transformed) | G | β: 0.049 | 2E-33 | PubMed |
| Weight (minimum, inv-normal transformed) | G | β: 0.045 | 5E-33 | PubMed |
| Body mass index (BMI, mean, inv-normal transformed) | G | β: 0.043 | 1E-28 | PubMed |
| Body mass index (BMI, maximum, inv-normal transformed) | G | β: 0.043 | 8E-27 | PubMed |
Other Variants in MCM6