RS4986790 Unknown gene
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What This Variant Does
"rs4986790, a SNP also known as Asp299Gly (and also 896A/G) in the TLR4 gene, is often studied along ...
GWAS Studies (10)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| TLR4 protein levels | G | OR: 0.29 | 1E-105 | PubMed |
| Toll-like receptor 4:Lymphocyte antigen 96 complex levels (TLR4.LY96.3647.49.4) | G | OR: 0.9 | 3E-70 | PubMed |
| IL27 protein levels | G | OR: 0.12 | 1E-32 | PubMed |
| Prostate-specific antigen levels | A | β: 0.065 | 7E-17 | PubMed |
| Basophil (fraction, mean, inv-norm transformed) | A | β: 0.062 | 7E-17 | PubMed |
| Basophil (fraction, minimum, inv-norm transformed) | A | β: 0.051 | 2E-14 | PubMed |
| Basophil (fraction, mean, inv-norm transformed) | A | β: 0.051 | 1E-13 | PubMed |
| Basophil (fraction, maximum, inv-norm transformed) | A | β: 0.044 | 2E-11 | PubMed |
| Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) | — | — | 1E-8 | PubMed |
| Crohn's disease | — | OR: 0.13 | 6E-6 | PubMed |