Genetic variant
rs495828
rs495828 is a single-letter difference in human DNA, on chromosome 9. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs495828 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
A common variant of the ABO gene protects against hypertension in a Spanish population. Pharmacogene...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs495828, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs495828
- Position
- chr9:133279294
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Hemoglobin levels | T | β 0.065 | 1E-124 | PubMed |
| LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) | T | — | 4E-103 | PubMed |
| LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) | T | — | 5E-69 | PubMed |
| Hematological and biochemical traits | T | OR 0.31 | 4E-59 | PubMed |
| Height | T | β 0.011 | 3E-46 | PubMed |
| Protein levels in obesity | — | OR 0.5 | 9E-40 | PubMed |
| DSGEGDFXAEGGGVR-to-ADpSGEGDFXAEGGGVR ratio | T | β 0.088 | 6E-34 | PubMed |
| Cadherin-5 levels | — | OR 0.33 | 4E-29 | PubMed |
| Hemoglobin A1c levels | T | β 0.053 | 2E-24 | PubMed |
| Hemoglobin levels | T | OR 0.1 | 1E-19 | PubMed |
| SCARF1 protein levels | T | β 0.057 | 5E-17 | PubMed |
| Venous thromboembolism | T | OR 1.65 | 3E-16 | PubMed |
| Blood protein levels in cardiovascular risk | T | OR 0.17 | 6E-13 | PubMed |
| Apolipoprotein B to apolipoprotein A1 ratio (UKB data field 23441) | T | β 0.041 | 7E-13 | PubMed |
| F2R protein levels | T | β 0.05 | 9E-13 | PubMed |
| COVID-19 or coronary artery disease (pleiotropy) | T | OR 0.93 | 1E-12 | PubMed |
| COVID-19 or hypertension (pleiotropy) | T | OR 0.95 | 2E-12 | PubMed |
| Red blood cell count | T | β 0.091 | 3E-12 | PubMed |
| Coronary artery disease | T | β 0.06 | 9E-12 | PubMed |
| Breast cancer or ovarian cancer (pleiotropy) | G | — | 7E-11 | PubMed |
Sources
- dbSNP: rs495828 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies