Genetic variant
rs4939883
rs4939883 is a single-letter difference in human DNA, on chromosome 18. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4939883 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
C allele is associated with 1.87mg/dl increase in HDL cholesterol (good cholesterol). [GWAS:Cholest...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4939883, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4939883
- Position
- chr18:49640844
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Low-density lipoprotein levels (MTAG) | T | β 0.04 | 2E-107 | PubMed |
| Phospholipids in small HDL (UKB data field 23574) | T | β 0.09 | 1E-49 | PubMed |
| Saturated fatty acids levels | T | — | 5E-47 | PubMed |
| Total lipid levels in small HDL | T | β 0.076 | 2E-45 | PubMed |
| High density lipoprotein cholesterol levels | T | β 0.064 | 2E-45 | PubMed |
| Total lipids in small HDL (UKB data field 23573) | T | β 0.079 | 2E-38 | PubMed |
| Polyunsaturated fatty acid levels | T | — | 2E-36 | PubMed |
| Polyunsaturated fatty acid levels | T | — | 1E-34 | PubMed |
| Omega-6 fatty acid levels | T | — | 2E-33 | PubMed |
| Linoleic acid levels | T | β 0.063 | 5E-33 | PubMed |
| Total cholesterol levels | T | β 0.056 | 2E-32 | PubMed |
| Concentration of small HDL particles | T | β 0.06 | 1E-28 | PubMed |
| Linoleic acid levels | T | — | 1E-25 | PubMed |
| Concentration of small HDL particles (UKB data field 23572) | T | β 0.063 | 8E-25 | PubMed |
| Cholesterol in small HDL (UKB data field 23575) | T | β 0.062 | 2E-24 | PubMed |
| HDL cholesterol levels | T | β 0.014 | 3E-23 | PubMed |
| Total lipids in small HDL | T | β 0.049 | 8E-21 | PubMed |
| Concentration of small HDL particles | T | β 0.049 | 1E-20 | PubMed |
| Cholesterol percentage of total lipids in small low-density lipoprotein | T | β 0.037 | 2E-19 | PubMed |
| Cholesteryl esters in small HDL (UKB data field 23576) | T | β 0.055 | 5E-19 | PubMed |
Sources
- dbSNP: rs4939883 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies