Genetic variant
rs492602
rs492602 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs492602 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
From : We identified a strong association (p = 5.36 x 10(-17)) between rs492602 in the FUT2 gene and...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs492602, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs492602
- Position
- chr19:48703160
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Serum alkaline phosphatase levels | G | OR 0.12 | 1E-566 | PubMed |
| FGF19 protein levels | G | OR 0.21 | 4E-290 | PubMed |
| Protein FAM3D levels | A | OR 0.45 | 3E-268 | PubMed |
| REG1B protein levels | G | OR 0.16 | 2E-191 | PubMed |
| Human milk oligosaccharide concentration (2'-fucosyllactose) | A | OR 28.72 | 2E-181 | PubMed |
| HEPH protein levels | G | OR 0.15 | 4E-164 | PubMed |
| Human milk oligosaccharide concentration (lacto-N-fucopentaose-I) | A | OR 26.84 | 1E-158 | PubMed |
| Human milk oligosaccharide concentration (Fucose-bound) | A | OR 26.58 | 1E-155 | PubMed |
| Tissue factor levels | A | OR 0.21 | 1E-142 | PubMed |
| Intestinal-type alkaline phosphatase levels | A | OR 0.32 | 5E-128 | PubMed |
| Total concentration of 19 human milk oligosaccharides | A | OR 22.95 | 1E-116 | PubMed |
| Human milk oligosaccharide concentration (difucosyllactose) | A | OR 22.64 | 2E-113 | PubMed |
| Human milk oligosaccharide concentration (lacto-N-fucopentaose-II) | A | OR 22.64 | 2E-113 | PubMed |
| Lithostathine-1-beta levels | A | OR 0.26 | 2E-83 | PubMed |
| Human milk oligosaccharide concentration (fucodisialyllacto-N-hexaose) | A | OR 19.35 | 2E-83 | PubMed |
| FOLR1 protein levels | G | β 0.096 | 2E-78 | PubMed |
| Golgi membrane protein 1 levels | A | OR 0.25 | 4E-78 | PubMed |
| CEACAM6 protein levels | G | β 0.09 | 7E-68 | PubMed |
| Fibroblast growth factor 19 levels | A | OR 0.23 | 6E-65 | PubMed |
| Intestinal-type alkaline phosphatase (analyte X17441.4) levels | G | OR 0.39 | 2E-50 | PubMed |
Sources
- dbSNP: rs492602 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies