Genetic variant
rs4810485
rs4810485 is a single-letter difference in human DNA, on chromosome 20. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4810485 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs4810485 is a SNP associated with rheumatoid arthritis (RA), a chronic autoimmune disease character...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4810485, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4810485
- Position
- chr20:46119308
Genome-wide association studies (12)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Tumor necrosis factor receptor superfamily member 5 levels | T | OR 0.47 | 1E-414 | PubMed |
| CD27 on unswitched memory B cell | G | OR 0.48 | 6E-78 | PubMed |
| IgD- CD27- B cell %B cell | G | OR 0.39 | 7E-50 | PubMed |
| IgD- CD27- B cell %lymphocyte | G | OR 0.32 | 5E-33 | PubMed |
| CD40 levels | — | OR 0.33 | 5E-19 | PubMed |
| CD40 protein levels | G | OR 0.53 | 6E-16 | PubMed |
| Multiple sclerosis | A | OR 1.11 | 8E-16 | PubMed |
| Rheumatoid arthritis (ACPA-positive) | — | — | 9E-11 | PubMed |
| Rheumatoid arthritis | T | OR 0.85 | 3E-9 | PubMed |
| Rheumatoid arthritis | G | OR 1.15 | 8E-9 | PubMed |
| Systemic lupus erythematosus | — | OR 1.43 | 1E-8 | PubMed |
| Rheumatoid arthritis | — | — | 2E-7 | PubMed |
Sources
- dbSNP: rs4810485 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies