Genetic variant

rs4775041

rs4775041 is a single-letter difference in human DNA, on chromosome 15. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4775041 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

rs4775041 is a SNP located near the LIPC gene. A study of metabolite concentrations in the blood of ...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4775041, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs4775041
Position
chr15:58382496

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Phosphatidylethanolamine_38:6_[M-H]1- levels C OR 0.27 9E-103 PubMed
High density lipoprotein cholesterol levels G OR 0.12 2E-102 PubMed
Phosphatidylcholine_33:4_[M+H]1+/Phosphatidylethanolamine_36:4_[M+H]1+/Phosphatidate_38:5_[M+NH4]1+ levels C OR 0.27 2E-101 PubMed
Phosphatidylcholine_35:6_[M+H]1+/Phosphatidylethanolamine_38:6_[M+H]1+/Phosphatidate_40:7_[M+NH4]1+ levels C OR 0.27 2E-94 PubMed
Phosphatidylcholine_35:4_[M+H]1+/Phosphatidylethanolamine_38:4_[M+H]1+/Phosphatidate_40:5_[M+NH4]1+ levels C OR 0.25 2E-86 PubMed
Phosphatidylethanolamine_36:4_[M-H]1- levels C OR 0.24 3E-83 PubMed
Phosphatidylcholine_31:2_[M+H]1+/Phosphatidylethanolamine_34:2_[M+H]1+/Phosphatidate_36:3_[M+NH4]1+ levels C OR 0.23 1E-69 PubMed
Phosphatidylethanolamine_34:2_[M-H]1- levels C OR 0.18 4E-46 PubMed
Phosphatidylcholine_37:6_[M+H]1+/Phosphatidylethanolamine_40:6_[M+H]1+/Phosphatidate_42:7_[M+NH4]1+ levels C OR 0.2 5E-39 PubMed
Phosphatidylethanolamine_38:5_[M-H]1- levels C OR 0.11 4E-26 PubMed
Total cholesterol levels G β 0.049 1E-25 PubMed
Diacylglycerol_38:6_[M+H-H2O]1+ levels C OR 0.1 2E-21 PubMed
HDL cholesterol C OR 1.38 3E-20 PubMed
Phosphatidylethanolamine_36:3_[M-H]1- levels C β 0.092 1E-16 PubMed
Lysophosphatidylethanolamine_16:0_[M-H]1- levels C β 0.095 2E-16 PubMed
Phosphatidylethanolamine_34:1_[M-H]1- levels C β 0.089 6E-16 PubMed
Triglycerides G β 0.034 7E-16 PubMed
Phosphatidylethanolamine_38:4_[M-H]1- levels C β 0.066 1E-13 PubMed
Phosphatidylethanolamine(36:4)_[M+H]1+ levels C β 0.058 1E-11 PubMed
Phosphatidylethanolamine(38:5)_[M-H]1- levels A β 0.04 1E-11 PubMed

Sources