Genetic variant
rs4731702
rs4731702 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4731702 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
http://www.medhours.com/master-gene-controls-fat-metabolism/ The enrichment of rs4731702 trans assoc...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4731702, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4731702
- Position
- chr7:130748625
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglyceride levels | T | β 0.032 | 3E-82 | PubMed |
| Hip index | T | β 0.055 | 3E-79 | PubMed |
| Hip circumference adjusted for BMI | T | β 0.044 | 2E-56 | PubMed |
| Triglyceride levels | T | β 0.025 | 1E-48 | PubMed |
| Triglycerides | T | β 0.03 | 3E-47 | PubMed |
| Type 2 diabetes | C | — | 3E-41 | PubMed |
| High density lipoprotein cholesterol levels | C | β 0.033 | 2E-21 | PubMed |
| Body fat percentage and HDL-C (pairwise) | T | — | 5E-20 | PubMed |
| HDL cholesterol levels | T | β 0.029 | 1E-17 | PubMed |
| HDL cholesterol | T | β 0.029 | 5E-17 | PubMed |
| Hypertension | T | OR 7.98 | 1E-15 | PubMed |
| HDL cholesterol | T | OR 0.59 | 1E-15 | PubMed |
| Diastolic blood pressure | T | OR 0.11 | 2E-15 | PubMed |
| Systolic blood pressure | T | OR 0.17 | 5E-15 | PubMed |
| HDL cholesterol levels | T | β 0.009 | 1E-14 | PubMed |
| Triglycerides | C | β 0.029 | 2E-14 | PubMed |
| Diastolic blood pressure | T | OR 0.12 | 7E-14 | PubMed |
| Systolic blood pressure | T | OR 0.18 | 2E-11 | PubMed |
| Phospholipids to Total Lipids in Chylomicrons and Extremely Large VLDL percentage | T | β 0.01 | 2E-11 | PubMed |
| Body fat percentage and triglycerides (pairwise) | T | — | 4E-11 | PubMed |
Sources
- dbSNP: rs4731702 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies