Genetic variant
rs459193
rs459193 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs459193 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Replication Study in a Japanese Population to Evaluate the Association between 10 SNP Loci, Identified in European Genome-Wide Association Studies, and Type 2 Diabetes
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs459193, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs459193
- Position
- chr5:56510924
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Waist-to-hip ratio adjusted for BMI | A | β 0.029 | 3E-49 | PubMed |
| Glucose (fasting status unknown, mean, inv-norm transformed) | A | β 0.041 | 3E-44 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | A | β 0.038 | 1E-39 | PubMed |
| Diabetes mellitus (PheCode 250) | A | β 0.068 | 2E-37 | PubMed |
| Type 2 diabetes (PheCode 250.2) | A | β 0.068 | 5E-37 | PubMed |
| Glucose (fasting status unknown, maximum, inv-norm transformed) | A | β 0.036 | 9E-37 | PubMed |
| Albumin levels | A | β 0.021 | 1E-36 | PubMed |
| Diabetes / "Sugar" | A | β 0.074 | 2E-34 | PubMed |
| Metabolic syndrome | — | β 0.027 | 4E-33 | PubMed |
| high density lipoprotein cholesterol (HDLC, mean, inv-norm transformed) | A | β 0.038 | 3E-32 | PubMed |
| high density lipoprotein cholesterol (HDLC, maximum, inv-norm transformed) | A | β 0.036 | 3E-30 | PubMed |
| Type 2 diabetes | G | β 0.1 | 6E-30 | PubMed |
| Triglycerides | A | β 0.032 | 9E-29 | PubMed |
| Linoleic acid to total fatty acids percentage | G | β 0.02 | 1E-27 | PubMed |
| Waist-hip ratio and HDL-C (pairwise) | A | — | 4E-25 | PubMed |
| Diabetic retinopathy (PheCode 250.7) | A | β 0.087 | 7E-25 | PubMed |
| Hemoglobin A1c (HbA1c, maximum, inv-norm transformed) | A | β 0.033 | 2E-24 | PubMed |
| triglyceride (minimum, inv-norm transformed) | A | β 0.029 | 6E-24 | PubMed |
| HDL cholesterol | A | β 0.029 | 2E-23 | PubMed |
| Hemoglobin A1c (HbA1c, mean, inv-norm transformed) | A | β 0.033 | 2E-23 | PubMed |
Sources
- dbSNP: rs459193 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies