Genetic variant
rs445925
rs445925 is a single-letter difference in human DNA, on chromosome 19. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs445925 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs445925 can be used as a proxy for rs7412, based on a correlation of ~0.76 - 0.87 in at least some ...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs445925, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs445925
- Position
- chr19:44912383
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Triglycerides in HDL | A | OR 0.23 | 5E-497 | PubMed |
| Triglycerides in HDL | A | OR 0.19 | 1E-417 | PubMed |
| LDLR/MEGF9 protein level ratio | — | OR 0.41 | 6E-330 | PubMed |
| LDLR/PCSK9 protein level ratio | — | OR 0.4 | 5E-317 | PubMed |
| Very low density lipoprotein cholesterol levels | — | OR 6.26 | 1E-300 | PubMed |
| Low density lipoprotein cholesterol levels | — | OR 18.06 | 1E-300 | PubMed |
| Total cholesterol levels | — | — | 1E-256 | PubMed |
| Triglyceride to phosphoglyceride ratio | A | OR 0.14 | 3E-197 | PubMed |
| LDL cholesterol levels | A | OR 0.52 | 1E-129 | PubMed |
| Triglyceride to phosphoglyceride ratio | A | β 0.097 | 1E-108 | PubMed |
| ANGPTL3/TFPI protein level ratio | — | OR 0.19 | 1E-85 | PubMed |
| PDGFC/TFPI protein level ratio | — | OR 0.19 | 1E-68 | PubMed |
| LDL cholesterol levels | A | OR 0.57 | 4E-59 | PubMed |
| Lipoprotein-associated phospholipase A2 activity and mass | T | β 0.071 | 1E-56 | PubMed |
| NPY protein levels | A | OR 0.12 | 2E-49 | PubMed |
| HEXIM1/TARBP2 protein level ratio | — | OR 0.16 | 6E-49 | PubMed |
| AXIN1/HEXIM1 protein level ratio | — | OR 0.15 | 7E-47 | PubMed |
| ITGB1/TFPI protein level ratio | — | OR 0.15 | 2E-45 | PubMed |
| HEXIM1/SRPK2 protein level ratio | — | OR 0.15 | 3E-44 | PubMed |
| Metabolite levels | — | — | 6E-42 | PubMed |
Sources
- dbSNP: rs445925 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies