Genetic variant
rs4410790
rs4410790 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4410790 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs4410790 and rs2470893 influences habitual caffeine consumption [GWAS:None]
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4410790, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4410790
- Position
- chr7:17244953
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Caffeine consumption from coffee or tea | T | β 0.081 | 2E-249 | PubMed |
| Coffee consumption (cups per day) | T | β 0.057 | 1E-150 | PubMed |
| Coffee consumption | C | β 0.039 | 4E-142 | PubMed |
| Caffeine consumption from coffee | T | β 0.052 | 3E-104 | PubMed |
| Total bilirubin levels | T | β 0.032 | 5E-83 | PubMed |
| Bitter non-alcoholic beverage consumption | C | β 0.031 | 3E-75 | PubMed |
| Coffee consumption (cups per day) | C | OR 0.11 | 6E-70 | PubMed |
| Coffee consumption | — | OR 0.21 | 8E-68 | PubMed |
| Caffeine consumption from tea | T | β 0.04 | 1E-67 | PubMed |
| Bitter beverage consumption | C | β 0.027 | 5E-58 | PubMed |
| Total bilirubin levels (UKB data field 30840) | C | β 0.024 | 5E-56 | PubMed |
| Urinary albumin-to-creatinine ratio | C | β 0.024 | 2E-30 | PubMed |
| Tea consumption | C | β 0.018 | 3E-30 | PubMed |
| Urinary albumin-to-creatinine ratio | T | β 0.022 | 2E-26 | PubMed |
| Urinary albumin excretion | C | β 0.018 | 3E-25 | PubMed |
| Urinary albumin-to-creatinine ratio | T | β 0.021 | 7E-25 | PubMed |
| Triglyceride levels | T | β 0.016 | 1E-23 | PubMed |
| Cholesteryl Esters to Total Lipids in Large HDL percentage | C | β 0.02 | 4E-22 | PubMed |
| X-21286 levels | T | β 0.099 | 2E-21 | PubMed |
| Triglycerides to Total Lipids in Large HDL percentage | C | β 0.02 | 3E-21 | PubMed |
Sources
- dbSNP: rs4410790 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies