Genetic variant
rs429608
rs429608 is a single-letter difference in human DNA, on chromosome 6. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs429608 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs429608, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs429608
- Position
- chr6:31962685
Genome-wide association studies (14)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Macular degeneration, dry (PheCode 362.21) | G | OR 0.33 | 4E-110 | PubMed |
| Degeneration of macula and posterior pole of retina (PheCode 362.2) | G | OR 0.2 | 1E-91 | PubMed |
| Age-related macular degeneration | G | OR 1.74 | 4E-89 | PubMed |
| Macular degeneration (senile) of retina NOS (PheCode 362.29) | G | OR 0.43 | 2E-75 | PubMed |
| Macular degeneration (senile) of retina NOS (PheCode 362.29) | G | OR 0.4 | 9E-71 | PubMed |
| Macular degeneration, wet (PheCode 362.22) | G | OR 0.51 | 1E-69 | PubMed |
| Degeneration of macula and posterior pole of retina (PheCode 362.2) | G | OR 0.15 | 1E-54 | PubMed |
| Macular degeneration | G | OR 0.26 | 3E-46 | PubMed |
| Macular degeneration | G | OR 0.22 | 4E-38 | PubMed |
| Takes medication for Macular Degeneration? | G | OR 0.35 | 5E-35 | PubMed |
| Takes medication for Macular Degeneration? | G | OR 0.3 | 5E-33 | PubMed |
| Age-related macular degeneration | G | OR 2.16 | 3E-21 | PubMed |
| Age-related macular degeneration | — | OR 1.85 | 5E-15 | PubMed |
| Whole body fat mass (UKB data field 23100) | A | β 0.023 | 1E-12 | PubMed |
Sources
- dbSNP: rs429608 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies