Genetic variant
rs4272
rs4272 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs4272 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
One of 42 more SNPs associated with rheumatoid arthritis based on a meta-analysis of 30,000 patients...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs4272, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs4272
- Position
- chr7:92607515
Genome-wide association studies (19)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Monocyte side scatter | G | β 0.097 | 3E-30 | PubMed |
| Pulse pressure | G | OR 11.14 | 8E-29 | PubMed |
| Granulocyte percentage of myeloid white cells | G | β 0.049 | 2E-28 | PubMed |
| systolic blood pressure (SBP, maximum, inv-normal transformed) | A | β 0.03 | 2E-24 | PubMed |
| Multi-trait sex score | — | — | 5E-21 | PubMed |
| Eosinophill count (UKB data field 30150) | G | β 0.022 | 2E-19 | PubMed |
| Multi-trait sex score | — | — | 4E-18 | PubMed |
| Pulse pressure | G | OR 8.36 | 6E-17 | PubMed |
| Basophil percentage of white cells variance | G | β 0.024 | 3E-16 | PubMed |
| Waist circumference adjusted for body mass index | G | β 0.031 | 4E-16 | PubMed |
| Mitochondrial DNA copy number (raw) | A | β 0.035 | 1E-15 | PubMed |
| Cerebrovascular disease (PheCode 433) | A | β 0.054 | 2E-14 | PubMed |
| Pulse pressure | G | OR 7.31 | 3E-13 | PubMed |
| Systolic blood pressure | G | OR 6.76 | 1E-11 | PubMed |
| Basophil count variance | G | β 0.019 | 3E-11 | PubMed |
| Eosinophil count | G | β 0.026 | 4E-9 | PubMed |
| Rheumatoid arthritis | G | OR 1.1 | 1E-8 | PubMed |
| Rheumatoid arthritis | A | β 0.097 | 3E-7 | PubMed |
| Systolic blood pressure | G | OR 5.07 | 4E-7 | PubMed |
Sources
- dbSNP: rs4272 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies