RS4244285 CYP2C19

Drug Response Chr 10:94781858 snv synonymous variant

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What This Variant Does

"rs4244285 is a SNP in the CYP2C19 gene, potentially encoding the CYP2C19*2 variant. This variant is ...

Associated Conditions

Acute coronary syndrome

Medication Interactions

Clopidogrel efficacy strong

CYP2C19*2 — poor metaboliser, reduced antiplatelet effect

Omeprazole metabolism strong

CYP2C19*2 — poor metaboliser, increased drug levels

Escitalopram metabolism moderate

CYP2C19*2 — may need dose reduction

Sertraline metabolism moderate

CYP2C19*2 — may need dose adjustment

Population Frequencies

gnomAD ALL

84.1%

1kG AFR

83%

1kG ALL

77.9%

1kG AMR

10.5%

1kG EAS

68.8%

1kG EUR

85.5%

1kG SAS

64.2%

Other Variants in CYP2C19