RS4240624 Unknown gene
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What This Variant Does
"Genetic variants in GCKR and PNPLA3 confer susceptibility to nonalcoholic fatty liver disease in obese individuals"
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Glycine levels | A | OR: 0.13 | 3E-394 | PubMed |
| Liver enzyme levels (alkaline phosphatase) | G | β: 0.015 | 2E-308 | PubMed |
| Cholesteryl Esters in Small HDL | A | OR: 0.12 | 2E-250 | PubMed |
| Cholesterol in Small HDL | A | OR: 0.11 | 4E-240 | PubMed |
| Concentration of small HDL particles | A | OR: 0.11 | 5E-219 | PubMed |
| Total lipids in small HDL | A | β: 0.1 | 1E-180 | PubMed |
| Total lipids in medium HDL | A | β: 0.09 | 2E-175 | PubMed |
| Phospholipids in small HDL | A | β: 0.1 | 2E-169 | PubMed |
| Phospholipids in medium HDL | A | β: 0.09 | 1E-163 | PubMed |
| Glycine levels | G | OR: 0.12 | 1E-90 | PubMed |
| Phospholipids to Total Lipids in IDL percentage | A | β: 0.07 | 6E-83 | PubMed |
| Glycine levels | G | OR: 0.13 | 3E-78 | PubMed |
| CES1 protein levels | A | OR: 0.15 | 3E-68 | PubMed |
| Glycine levels (UKB data field 23462) | G | OR: 0.14 | 3E-67 | PubMed |
| Concentration of HDL particles | G | OR: 0.12 | 3E-65 | PubMed |
| Total concentration of lipoprotein particles | G | OR: 0.12 | 5E-65 | PubMed |
| Sex hormone-binding globulin levels adjusted for BMI | A | β: 0.022 | 2E-59 | PubMed |
| Cholesterol levels in medium HDL | G | OR: 0.1 | 2E-54 | PubMed |
| Cholesteryl ester levels in medium HDL | G | OR: 0.1 | 2E-54 | PubMed |
| Apolipoprotein A1 levels | G | OR: 0.1 | 2E-52 | PubMed |