RS4149584 TNFRSF1A

Health Risk Chr 12:6333476 snv missense variant

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What This Variant Does

"rs4149584 is a SNP in the tumor necrosis factor receptor superfamily, member 1A TNFRSF1A gene. A lar...

Associated Conditions

TNF receptor-associated periodic fever syndrome (TRAPS)

Multiple sclerosis

susceptibility to

Autoinflammatory syndrome

TNF receptor-associated periodic fever syndrome (TRAPS)

Multiple sclerosis

susceptibility to

Autoinflammatory syndrome

GWAS Studies (3)

Trait	Risk Allele	OR / Beta	P-value	Study
Tumor necrosis factor receptor 1 levels	T	OR: 0.37	3E-36	PubMed
TNFRSF1A protein levels	T	OR: 0.23	4E-36	PubMed
Multiple sclerosis	T	OR: 1.58	5E-6	PubMed

Population Frequencies

gnomAD ALL

1kG AFR

0.2%

1kG ALL

99.4%

1kG AMR

98.7%

1kG EAS

100%

1kG EUR

98.1%

1kG SAS

100%

Other Variants in TNFRSF1A