RS4149056 SLCO1B1
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What This Variant Does
"rs4149056, also known as c.521T>
Associated Conditions
Rotor syndrome
simvastatin acid response - Metabolism/PK
Gilbert syndrome
rosuvastatin response - Metabolism/PK
simvastatin response - Toxicity
hmg coa reductase inhibitors response - Toxicity
atorvastatin response - Toxicity
atorvastatin response - Metabolism/PK
fluvastatin response - Metabolism/PK
fluvastatin response - Toxicity
lovastatin acid response - Metabolism/PK
simvastatin response - Metabolism/PK
lovastatin response - Metabolism/PK
pitavastatin response - Metabolism/PK
rosuvastatin response - Toxicity
Medication Interactions
Simvastatin toxicity
strong
SLCO1B1*5 — increased risk of statin myopathy
Atorvastatin toxicity
moderate
SLCO1B1*5 — moderate myopathy risk
GWAS Studies (20)
| Trait | Risk Allele | OR / Beta | P-value | Study |
|---|---|---|---|---|
| Glycochenodeoxycholate glucuronide (1) levels | T | OR: 0.85 | 6E-776 | PubMed |
| Glycochenodeoxycholate glucuronide (1) levels | C | OR: 1.01 | 4E-559 | PubMed |
| Glycochenodeoxycholate glucuronide (1) levels | C | OR: 0.89 | 3E-493 | PubMed |
| X-11905 levels | T | OR: 0.58 | 5E-373 | PubMed |
| Glycocholenate sulfate levels | T | OR: 0.56 | 8E-358 | PubMed |
| Isoleucine-to-X-11529 ratio | T | OR: 0.3 | 6E-328 | PubMed |
| X-11529 levels | T | OR: 0.3 | 6E-315 | PubMed |
| Metabolite levels (glycochenodeoxycholate glucuronide (1)) | C | OR: 0.98 | 5E-303 | PubMed |
| Tetradecanedioate levels | T | OR: 0.49 | 7E-270 | PubMed |
| Plasma glycochenodeoxycholate glucuronide (1) levels in chronic kidney disease | C | OR: 1.07 | 3E-266 | PubMed |
| Hexadecanedioate levels | T | OR: 0.48 | 2E-259 | PubMed |
| Glycodeoxycholate sulfate levels | T | OR: 0.48 | 7E-246 | PubMed |
| Hexadecenedioate (C16:1-DC) levels | C | OR: 0.64 | 1E-233 | PubMed |
| X-12063 levels | T | OR: 0.44 | 1E-222 | PubMed |
| Glycocholenate sulfate levels | C | OR: 0.61 | 4E-209 | PubMed |
| X-21467 levels | T | OR: 0.45 | 7E-208 | PubMed |
| Hexadecenedioate (C16:1-DC) levels | C | OR: 0.67 | 6E-193 | PubMed |
| Glycocholenate sulfate levels | C | OR: 0.66 | 1E-187 | PubMed |
| HpODE levels (311.2231_0.343) | — | OR: 0.57 | 5E-185 | PubMed |
| Octadecadienedioate (C18:2-DC) levels | C | OR: 0.64 | 4E-183 | PubMed |
Population Frequencies
gnomAD ALL
14.5%
1kG AFR
98.6%
1kG ALL
8.8%
1kG AMR
86.6%
1kG EAS
87.7%
1kG EUR
16.1%
1kG SAS
4.3%
Other Variants in SLCO1B1