Genetic variant

rs3846662

rs3846662 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.

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What is this?

Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs3846662 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.

news three SNPs that appear to have different effects in men and women rs3846662 rs2304130 rs2083637...

From SNPedia

Why might it matter?

ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.

Do I have this variant?

If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs3846662, if your test read this position.

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Connect this with your blood results

A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.

Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.

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What should I do next?

  1. Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
  2. Put it in context. Add your blood results, so the variant can be read against what your body is doing.
  3. Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
  4. Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
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This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.

Technical details

dbSNP ID
rs3846662
Position
chr5:75355259

Genome-wide association studies (20)

TraitRisk alleleOR / betaP-valueStudy
Free cholesterol in large LDL G β 0.04 4E-90 PubMed
Free cholesterol in IDL G β 0.04 8E-89 PubMed
Cholesterol in IDL G β 0.04 9E-88 PubMed
Free Cholesterol in LDL G β 0.04 9E-87 PubMed
Cholesteryl Esters in IDL G β 0.04 1E-85 PubMed
Clinical LDL cholesterol levels G β 0.04 3E-84 PubMed
Total lipids in IDL G β 0.04 3E-84 PubMed
Free cholesterol in small LDL G β 0.04 3E-82 PubMed
Total cholesterol minus HDL-C levels G β 0.04 1E-80 PubMed
Cholesterol in Large LDL G β 0.04 2E-80 PubMed
Phospholipids in large LDL G β 0.04 2E-79 PubMed
Total lipids in large LDL G β 0.04 2E-77 PubMed
Total cholesterol levels G β 0.04 2E-76 PubMed
Cholesteryl Esters in Large LDL G β 0.04 4E-76 PubMed
LDL cholesterol levels G β 0.04 8E-76 PubMed
Free cholesterol in medium LDL G β 0.04 9E-76 PubMed
Phospholipids in LDL G β 0.04 1E-75 PubMed
Total esterified cholesterol levels G β 0.04 6E-74 PubMed
Total Lipids in LDL G β 0.04 3E-72 PubMed
Triglycerides to Total Lipids in Very Small VLDL percentage G β 0.03 3E-71 PubMed

Sources