Genetic variant
rs3782886
rs3782886 is a single-letter difference in human DNA, on chromosome 12. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs3782886 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
23andMe blog coronary artery disease and heart attack SNP Risk Version Effect *rs646776 T 1.19 *rs17...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs3782886, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs3782886
- Position
- chr12:111672685
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Mean corpuscular hemoglobin | T | OR 0.13 | 1E-108 | PubMed |
| Mean corpuscular volume | T | OR 0.11 | 4E-72 | PubMed |
| High density lipoprotein cholesterol levels | C | β 0.084 | 4E-45 | PubMed |
| Alcoholic liver damage (PheCode 317.11) | — | — | 1E-43 | PubMed |
| Alcoholic liver damage (PheCode 317.11) | — | OR 0.64 | 1E-43 | PubMed |
| Alcohol use disorder | — | — | 2E-29 | PubMed |
| Weight | G | β 0.01 | 7E-20 | PubMed |
| Gout (PheCode 274.1) | — | OR 0.15 | 4E-18 | PubMed |
| Alcohol use disorder (consumption score) | C | OR 0.6 | 5E-17 | PubMed |
| Myocardial infarction | G | OR 1.49 | 6E-17 | PubMed |
| Height | T | β 0.045 | 5E-16 | PubMed |
| Myocardial infarction | A | OR 1.46 | 1E-14 | PubMed |
| Low-carbohydrate diet (LCD) score | C | — | 4E-14 | PubMed |
| Chronic pancreatitis (PheCode 577.2) | — | — | 9E-12 | PubMed |
| Serum uric acid levels | C | OR 8.93 | 4E-11 | PubMed |
| Hematological and biochemical traits | G | β 0.079 | 5E-9 | PubMed |
| Type 2 diabetes | T | β 0.061 | 3E-8 | PubMed |
| Hazardous alcohol drinking | — | — | 1E-7 | PubMed |
| Serum folate levels | — | — | 2E-7 | PubMed |
| Type 2 diabetes | T | OR 1.06 | 3E-7 | PubMed |
Sources
- dbSNP: rs3782886 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies