Genetic variant
rs35677470
rs35677470 is a single-letter difference in human DNA, on chromosome 3. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs35677470 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
rs35677470, also known as R206C, is a missense SNP in the deoxyribonuclease I-like 3 [DNASEIL3] gene...
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs35677470, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs35677470
- Position
- chr3:58197909
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| FCN2 protein levels | A | OR 0.11 | 3E-35 | PubMed |
| LGMN protein levels | A | OR 0.11 | 2E-32 | PubMed |
| Systemic sclerosis | A | OR 2.03 | 4E-31 | PubMed |
| Serum levels of protein HIST2H2BE | A | OR 0.39 | 1E-29 | PubMed |
| Histone H2B type 2-E levels | A | OR 0.25 | 2E-26 | PubMed |
| Histone H2B type 3-B levels | A | OR 0.24 | 8E-25 | PubMed |
| Limited cutaneous systemic scleroderma | A | OR 1.62 | 1E-20 | PubMed |
| Histone H2A type 3 levels | A | OR 0.2 | 7E-18 | PubMed |
| Serum levels of protein H2AFZ | A | OR 0.3 | 5E-17 | PubMed |
| Serum levels of protein LST1 | A | OR 0.28 | 8E-17 | PubMed |
| Systemic sclerosis | A | OR 1.6 | 1E-12 | PubMed |
| C1QTNF5 protein levels | A | β 0.071 | 1E-12 | PubMed |
| Autoimmune traits (pleiotropy) | A | — | 1E-11 | PubMed |
| Hypothyroidism | A | β 0.047 | 1E-11 | PubMed |
| Hypothyroidism | A | β 0.046 | 1E-11 | PubMed |
| Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) | A | OR 1.22 | 5E-9 | PubMed |
| Autoimmune thyroid disease | A | OR 1.1 | 9E-9 | PubMed |
| Rheumatoid arthritis | A | OR 1.2 | 2E-8 | PubMed |
| Rheumatoid arthritis | A | OR 1.1 | 2E-8 | PubMed |
| Rheumatoid arthritis | A | OR 1.19 | 2E-7 | PubMed |
Sources
- dbSNP: rs35677470 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies