Genetic variant
rs35658696
rs35658696 is a single-letter difference in human DNA, on chromosome 5. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs35658696 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
Rare and low-frequency coding variants alter human adult height.
From SNPedia
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs35658696, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs35658696
- Position
- chr5:103003107
Genome-wide association studies (16)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| Peptidyl-glycine alpha-amidating monooxygenase levels | A | OR 1.34 | 2E-485 | PubMed |
| Peptidyl-glycine alpha-amidating monooxygenase levels (PAM.5620.13.3) | G | OR 0.97 | 2E-67 | PubMed |
| Diabetes / "Sugar" | A | OR 0.13 | 5E-27 | PubMed |
| Takes medication for Diabetes/sugar? | A | OR 0.13 | 3E-26 | PubMed |
| Takes medication for Diabetes/sugar? | A | OR 0.14 | 3E-17 | PubMed |
| Type 2 diabetes | G | OR 1.13 | 1E-16 | PubMed |
| Height (baseline) | A | β 0.023 | 2E-16 | PubMed |
| Diabetic retinopathy (PheCode 250.7) | A | OR 0.16 | 1E-15 | PubMed |
| Type 2 diabetes (adjusted for BMI) | G | OR 1.13 | 7E-15 | PubMed |
| Type 2 diabetes (adjusted for BMI) | G | OR 1.13 | 4E-13 | PubMed |
| Fluid intelligence score (baseline) | A | β 0.042 | 1E-12 | PubMed |
| Electrocardiogram morphology (amplitude at temporal datapoints) | A | β 0.085 | 5E-12 | PubMed |
| Type 2 diabetes | G | OR 1.13 | 6E-12 | PubMed |
| Cognitive aspects of educational attainment | A | β 0.097 | 2E-9 | PubMed |
| Insulinogenic index | G | OR 0.15 | 2E-8 | PubMed |
| General cognitive ability | — | OR 4.9 | 9E-7 | PubMed |
Sources
- dbSNP: rs35658696 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies