Genetic variant
rs342296
rs342296 is a single-letter difference in human DNA, on chromosome 7. Carrying it does not, on its own, mean you have or will develop any condition.
What is this?
Your DNA is a long sequence of four letters. At a few million positions, people commonly differ by a single letter; each of those positions is called a SNP (“snip”), and rs342296 is the catalogue number of one of them. Which letters you carry there — one copy from each parent — is your genotype.
We hold only the basic reference record for this variant: its ID and position. Many catalogued variants have never been linked to anything.
Why might it matter?
ClinVar holds no clinical classification for this variant. That is the usual case: most catalogued variants have no known effect on health.
Do I have this variant?
If you have taken a consumer DNA test (23andMe, AncestryDNA and similar), you can download its raw data file and check. Create a free account, upload the file, and this page will show the letters you carry at rs342296, if your test read this position.
Connect this with your blood results
A gene is a fixed instruction; a blood test shows what your body is doing now. CheckMyBloods reads the two side by side, so a variant can be set against the markers it could plausibly affect.
Blood markers do not diagnose a genetic condition, and a variant does not explain a blood result on its own. Together, with symptoms and family history, they give a clinician context.
What should I do next?
- Find out whether you carry it. Reading about a variant says nothing about you until you know your genotype.
- Put it in context. Add your blood results, so the variant can be read against what your body is doing.
- Ask questions. Dr. Hemsworth, our AI assistant, can explain this variant and your results in plain English.
- Take anything that worries you to a professional. A GP or genetic counsellor can order a confirmatory test and interpret it with your history.
This page is general information drawn from public research databases. It cannot diagnose anything, and it is not a substitute for advice from a doctor or genetic counsellor who knows your history.
Technical details
- dbSNP ID
- rs342296
- Position
- chr7:106732457
Genome-wide association studies (20)
| Trait | Risk allele | OR / beta | P-value | Study |
|---|---|---|---|---|
| EDAR/ITGB1BP2 protein level ratio | — | OR 0.19 | 3E-170 | PubMed |
| DBNL/EDAR protein level ratio | — | OR 0.15 | 1E-108 | PubMed |
| CRADD/EDAR protein level ratio | — | OR 0.15 | 7E-104 | PubMed |
| COMT/ITGB1BP2 protein level ratio | — | OR 0.15 | 4E-101 | PubMed |
| EDAR/ERBIN protein level ratio | — | OR 0.15 | 2E-100 | PubMed |
| EDAR/SNAP23 protein level ratio | — | OR 0.15 | 9E-99 | PubMed |
| EBAG9/EDAR protein level ratio | — | OR 0.14 | 9E-97 | PubMed |
| CD69/EDAR protein level ratio | — | OR 0.14 | 1E-94 | PubMed |
| CDKN2D/ITGB1BP2 protein level ratio | — | OR 0.14 | 2E-94 | PubMed |
| ITGB1BP2/MED18 protein level ratio | — | OR 0.14 | 2E-93 | PubMed |
| EDAR/ENO2 protein level ratio | — | OR 0.13 | 4E-84 | PubMed |
| EDAR/IRAK4 protein level ratio | — | OR 0.13 | 4E-80 | PubMed |
| EDAR/SERPINB1 protein level ratio | — | OR 0.13 | 5E-80 | PubMed |
| EDAR/IPCEF1 protein level ratio | — | OR 0.13 | 2E-79 | PubMed |
| EDAR/YES1 protein level ratio | — | OR 0.13 | 3E-75 | PubMed |
| CXCL11/ITGB1BP2 protein level ratio | — | OR 0.13 | 5E-75 | PubMed |
| EDAR/F2R protein level ratio | — | OR 0.13 | 1E-73 | PubMed |
| EDAR/TACC3 protein level ratio | — | OR 0.12 | 2E-71 | PubMed |
| AXIN1/ITGB1BP2 protein level ratio | — | OR 0.12 | 1E-70 | PubMed |
| ITGB1BP2/PLXNA4 protein level ratio | — | OR 0.12 | 1E-66 | PubMed |
Sources
- dbSNP: rs342296 — the reference record
- ClinVar — clinical interpretations submitted by laboratories
- SNPedia — community-written summaries
- GWAS Catalog — association studies